Management of germ cell tumors: A case report and discussion

Abstract

Malignant ovarian germ cell tumors (MOGCTs) are rare. Unlike epithelial ovarian cancer, MOGCTs typically occur in girls and young women. Fertility-sparing surgery and platinum-based chemotherapy remain the standard of care, providing high chance of cure at
all stages. Given the lack of high-quality studies in this field, current practice guidelines recommend chemotherapy regimens adopted in testicular germ cell tumors. However, platinum-resistant/refractory MOGCTs retain a worse prognosis in comparison with their
male counterpart. Herein, we focus on current systemic anti-cancer treatment options in MOGCTs and promising approaches.